Less Can Be More

Less Can Be More for Gene Dose and Drug Sensitivity.

CDK4 is preclinically validated as a therapeutic target in PAX3-FOXO1 fusion gene-positive rhabdomyosarcomas. Pharmacologic targeting showed sensitivity but, contrary to expectation, CDK4 genomic amplification and overexpression associated with 25% of cases that exhibited the lowest sensitivities. This emphasizes the importance of tumor-specific preclinical studies to define and understand drug...

Supplier Capacity and Intermediary Profits: Can Less Be More?

Elodie Adida Operations and Supply Chain Management, School of Business Administration, University of California at Riverside, 225 Anderson Hall, 900 University Ave., Riverside CA 92521, USA, [email protected] Nitin Bakshi Management Science and Operations, London Business School, Regent’s Park, London NW1 4SA, UK, [email protected] Victor DeMiguel Management Science and Operations, Londo...

Ablation of Atrial Fibrillation: How Can Less Be More?

Physical examination checklist for medical students: can less be more?

As part of their training, medical students and postgraduates are usually required to demonstrate competency in conducting physical examination skills for graduation and advancement. This is typically done by observing them perform a checklist of physical examination maneuvers in real or standardized patients. It is important that medical educators emphasize the importance of the art of physica...

Metronomic Chemotherapy: When Less May Be More

The use of low dose continuous schedules of chemotherapy (i.e. metronomic chemotherapy), delivered at lower doses by necessity compared to traditional dosing schemes, has become an increasingly popular addition to patient management in veterinary medical oncology. While the concept itself is not new, as low dose, maintenance chemotherapy protocols have been important components of treatment for...